GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12681963 | 1 | rs6468131 | chr8:29981020 | TMEM66 | chr8:29920632-29940649:- | 0.19 | 3.76 | 0.00019 | Migraine |
| THCA | cis | rs7814319 | 1 | rs6468495 | chr8:97259953 | PTDSS1 | chr8:97274167-97346774:+ | 0.18 | 3.92 | 0.000101 | Lung function (FVC) |
| THCA | cis | rs3091242 | 1 | rs646867 | chr1:25709258 | RHCE | chr1:25688741-25756683:- | 0.7 | 15.44 | 6.09E-44 | Erythrocyte sedimentation rate |
| THCA | cis | rs3091242 | 1 | rs646867 | chr1:25709258 | RHD | chr1:25598981-25656935:+ | -0.6 | -11.59 | 1.52E-27 | Erythrocyte sedimentation rate |
| THCA | cis | rs3091242 | 1 | rs646867 | chr1:25709258 | TMEM57 | chr1:25757388-25826696:+ | 0.18 | 4.59 | 5.6E-6 | Erythrocyte sedimentation rate |
| THCA | cis | rs13253073 | 1 | rs6468694 | chr8:100865836 | VPS13B | chr8:100025494-100889807:+ | -0.12 | -3.54 | 0.000432 | Glucose homeostasis traits |
| THCA | cis | rs6472235 | 1 | rs6472232 | chr8:66792632 | PDE7A | chr8:66629906-66753755:- | 0.15 | 3.34 | 0.000897 | Myopia (pathological) |
| THCA | cis | rs6472235 | 1 | rs6472238 | chr8:66850203 | PDE7A | chr8:66629906-66753755:- | 0.17 | 3.69 | 0.00025 | Myopia (pathological) |
| THCA | cis | rs523340 | 1 | rs6477692 | chr9:111904758 | C9orf5 | chr9:111777416-111882225:- | 0.2 | 3.73 | 0.000214 | Information processing speed |
| THCA | cis | rs6477998 | 1 | rs6477998 | chr9:115997249 | AMBP | chr9:116822410-116840752:- | 0.16 | 3.38 | 0.000795 | Hematology traits |
| THCA | cis | rs6477998 | 1 | rs6477998 | chr9:115997249 | CDC26 | chr9:116029290-116037869:- | 0.4 | 9.07 | 3.11E-18 | Hematology traits |
| THCA | cis | rs6477998 | 1 | rs6477998 | chr9:115997249 | PRPF4 | chr9:116037974-116055054:+ | -0.17 | -4.08 | 5.34E-5 | Hematology traits |
| THCA | cis | rs881375 | 1 | rs6478484 | chr9:123652380 | LOC253039 | chr9:123605320-123616644:+ | -0.5 | -9.21 | 1.07E-18 | Rheumatoid arthritis |
| THCA | cis | rs881375 | 1 | rs6478484 | chr9:123652380 | PSMD5 | chr9:123578334-123605206:- | -0.26 | -5.19 | 3.06E-7 | Rheumatoid arthritis |
| THCA | cis | rs881375 | 1 | rs6478486 | chr9:123655329 | LOC253039 | chr9:123605320-123616644:+ | -0.5 | -9.11 | 2.3E-18 | Rheumatoid arthritis |